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Propranolol modulates value-free random exploration

In our recent paper, we are investigating the catecholaminergic bases of different exploration strategies. Previously it was thought that exploration-exploitation trade-off is solved by using computationally demanding exploration algorithms, however, we show that humans also use additional computationally cheaper strategies using a newly developed 3-armed bandit task. Furthermore, we show that one of these heuristics, value-free random exploration (ϵ-greedy), is modulated by noradrenaline. Upon administration of a single dose of propranolol, we found a reduction in value-free random exploration. This could be interesting in the context of disorders of exploration, such as attention-deficit/hyperactivity disorder and how aberrant catecholamine function might contribute to the core behavioural impairments. More information can be found here:Dubois M, Habicht J, Michely J, Moran R, Dolan RJ & Hauser TU (2021). Human complex exploration strategies are enriched by noradrenaline-modulated heuristics eLife 10:e59907

A rise of OCD: OCD symptoms are more affected by the Covid-19 pandemic than other mental health symptoms.

In our new preprint, we present data of our longitudinal study in which we tracked obsessive-compulsive, anxiety and depression symptoms in the general public during the first Covid-19 pandemic wave. We show an elevation across all psychiatric symptoms. However, while depression scores decreased and anxiety symptoms remained stable over time, obsessive-compulsive symptoms rose further even though the peak of the first pandemic wave had passed. These OC symptoms were directly linked to Covid-related information seeking which gave rise to a higher adherence to government Covid-19 guidelines. For more details, see here: Loosen, A. M., Skvortsova, V., & Hauser, T. U. (2020). A Selective Increase in OC Symptoms is Driving Information Seeking and Guideline Adherence During the Covid-19 Pandemic. MedRxiv, 2020.12.08.20245803.

Making a case for a computational psychiatry of juvenile obsessive-compulsive disorder

In a recent paper published in Neuroscience & Biobehavioral Reviews, we review studies relevant to a computational psychiatry of juvenile OCD. Our investigation shows that juvenile OCD is mainly characterised by the disruption of complex reasoning systems. Based on reviewed findings, we suggest a new neurocomputational framework that illustrates how observed alterations may arise with development. Providing testable hypotheses this framework can now guide future research endeavours. More information can be found here: Loosen AM & Hauser TU (2020). Towards a computational psychiatry of juvenile obsessive-compulsive disorder Neuroscience and Biobehavioral Reviews 14;118:631-642 

ERC Starting Grant awarded

It is our great pleasure to announce that Tobias was awarded the European Research Council (ERC) Starting Grant to study the impact of endogenous brain fluctuations on decision-making. This will help us to undertake new and exiting research using a novel neuroimaging framework, which will strengthen the understanding in how the inner workings of the brain guide our behaviour.

Why is it important to study mental health in youth?

In the light of today’s Youth Mental Health Day we discuss why it is important to study how and why mental health problems emerge during adolescents at Wellcome Centre for Human Neuroimaging website. Three-quarters of mental health disorders arise before mid-20s. How is the emergence of mental health problems related to the rapid brain development during adolescents?  This is what our group and many others are trying to understand. Please go and visit Wellcome Centre for Human Neuroimaging website for the full discussion on the importance of studying mental health in development and how our team has contributed to better understand the relationship between brain development and psychiatric disorders.

Newest addition to our team

We are happy to announce that our group has expanded and Vasilisa Skvortsova has joined us as a Postdoctoral Fellow. She is a talented addition to our team and we are so excited to have her working with us. Welcome aboard Vasilisa!