In a recent paper that we have just published in Journal of Neuroscience, we show that Information Gathering can be modulated using the noradrenergic Beta-Receptorblocker Propranolol. Upon a single dose propranolol, we found a reduction in information gathering. Computational modelling revealed that this is due to an earlier rise of an internal urgency signal, which promotes timely decisions. This could be interesting in the context of OCD, because we found a delay in this urgency signal in patients with OCD.
Hauser TU, Moutoussis M, Purg N, Dayan P* & Dolan RJ* (2018). Beta-blocker propranolol modulates decision urgency during sequential information gathering. J Neurosci 38 (32) 7170-7178